313 research outputs found
The tail of the contact force distribution in static granular materials
We numerically study the distribution P(f) of contact forces in frictionless
bead packs, by averaging over the ensemble of all possible force network
configurations. We resort to umbrella sampling to resolve the asymptotic decay
of P(f) for large f, and determine P(f) down to values of order 10^{-45} for
ordered and disordered systems in two and three dimensions. Our findings
unambiguously show that, in the ensemble approach, the force distributions
decay much faster than exponentially: P(f) ~ exp(-f^{\alpha}), with alpha
\approx 2.0 for 2D systems, and alpha \approx 1.7 for 3D systems.Comment: 4 pages, 4 figures, submitted to Phys. Rev.
Bounds on the shear load of cohesionless granular matter
We characterize the force state of shear-loaded granular matter by relating
the macroscopic stress to statistical properties of the force network. The
purely repulsive nature of the interaction between grains naturally provides an
upper bound for the sustainable shear stress, which we analyze using an
optimization procedure inspired by the so-called force network ensemble. We
establish a relation between the maximum possible shear resistance and the
friction coefficient between individual grains, and find that anisotropies of
the contact network (or the fabric tensor) only have a subdominant effect.
These results can be considered the hyperstatic limit of the force network
ensemble and we discuss possible implications for real systems. Finally, we
argue how force anisotropies can be related quantitatively to experimental
measurements of the effective elastic constants.Comment: 17 pages, 6 figures. v2: slightly rearranged, introduction and
discussion rewritte
Ensemble Theory for Force Networks in Hyperstatic Granular Matter
An ensemble approach for force networks in static granular packings is
developed. The framework is based on the separation of packing and force
scales, together with an a-priori flat measure in the force phase space under
the constraints that the contact forces are repulsive and balance on every
particle. In this paper we will give a general formulation of this force
network ensemble, and derive the general expression for the force distribution
. For small regular packings these probability densities are obtained in
closed form, while for larger packings we present a systematic numerical
analysis. Since technically the problem can be written as a non-invertible
matrix problem (where the matrix is determined by the contact geometry), we
study what happens if we perturb the packing matrix or replace it by a random
matrix. The resulting 's differ significantly from those of normal
packings, which touches upon the deep question of how network statistics is
related to the underlying network structure. Overall, the ensemble formulation
opens up a new perspective on force networks that is analytically accessible,
and which may find applications beyond granular matter.Comment: 17 pages, 17 figure
Effects of JL13, a Pyridobenzoxazepine with Potential Atypical Antipsychotic Activity, in Animal Models for Schizophrenia
ABSTRACT JL13 [5-(4-methylpiperazin-1-yl)-8-chloro-pyrido [2,3-b][1,5] benzoxazepine fumarate] is a substance with a close structural resemblance to clozapine. However, it is less sensitive to oxidation and may therefore have less hematological side effects. In the present study, JL13 was compared with clozapine and haloperidol in several animal models for schizophrenia. The paw test represents a screening model for antipsychotic drugs that can discriminate between drugs with extrapyramidal side effects and drugs without. Haloperidol increased both forelimb retraction time and hindlimb retraction time (HRT), whereas both clozapine and JL13 increased only HRT. In the prepulse inhibition paradigm, all three drugs reversed the apomorphineand the amphetamine-induced disruption of prepulse inhibition. However, whereas haloperidol was equally effective against both dopaminergic drugs, JL13 and clozapine were more effective against amphetamine. Finally, only JL13 was able to increase prepulse inhibition in normal rats, whereas only clozapine reduced basal startle amplitude. Taken together, these data suggest that JL13 may be an effective antipsychotic drug, with a profile similar to clozapine
Strain-controlled criticality governs the nonlinear mechanics of fibre networks
Disordered fibrous networks are ubiquitous in nature as major structural
components of living cells and tissues. The mechanical stability of networks
generally depends on the degree of connectivity: only when the average number
of connections between nodes exceeds the isostatic threshold are networks
stable (Maxwell, J. C., Philosophical Magazine 27, 294 (1864)). Upon increasing
the connectivity through this point, such networks undergo a mechanical phase
transition from a floppy to a rigid phase. However, even sub-isostatic networks
become rigid when subjected to sufficiently large deformations. To study this
strain-controlled transition, we perform a combination of computational
modeling of fibre networks and experiments on networks of type I collagen
fibers, which are crucial for the integrity of biological tissues. We show
theoretically that the development of rigidity is characterized by a
strain-controlled continuous phase transition with signatures of criticality.
Our experiments demonstrate mechanical properties consistent with our model,
including the predicted critical exponents. We show that the nonlinear
mechanics of collagen networks can be quantitatively captured by the
predictions of scaling theory for the strain-controlled critical behavior over
a wide range of network concentrations and strains up to failure of the
material
Identification of an alternative triglyceride biosynthesis pathway
Triacylglycerols (TAGs) are the main source of stored energy in the body, providing an important substrate pool for mitochondrial beta-oxidation. Imbalances in the amount of TAGs are associated with obesity, cardiac disease and various other pathologies 1,2. In humans, TAGs are synthesized from excess, coenzyme A-conjugated fatty acids by diacylglycerol O-acyltransferases (DGAT1 and DGAT2) 3. In other organisms, this activity is complemented by additional enzymes 4, but whether such alternative pathways exist in humans remains unknown. Here we disrupt the DGAT pathway in haploid human cells and use iterative genetics to reveal an unrelated TAG-synthesizing system composed of a protein we called DIESL (also known as TMEM68, an acyltransferase of previously unknown function) and its regulator TMX1. Mechanistically, TMX1 binds to and controls DIESL at the endoplasmic reticulum, and loss of TMX1 leads to the unconstrained formation of DIESL-dependent lipid droplets. DIESL is an autonomous TAG synthase, and expression of human DIESL in Escherichia coli endows this organism with the ability to synthesize TAG. Although both DIESL and the DGATs function as diacylglycerol acyltransferases, they contribute to the cellular TAG pool under specific conditions. Functionally, DIESL synthesizes TAG at the expense of membrane phospholipids and maintains mitochondrial function during periods of extracellular lipid starvation. In mice, DIESL deficiency impedes rapid postnatal growth and affects energy homeostasis during changes in nutrient availability. We have therefore identified an alternative TAG biosynthetic pathway driven by DIESL under potent control by TMX1. </p
Localization behavior of vibrational modes in granular packings
We study the localization of vibrational modes of frictionless granular
media. We introduce a new method, motivated by earlier work on non-Hermitian
quantum problems, which works well both in the localized regime where the
localization length is much less than the linear size and in the
regime grater or of order when modes are extended throughout our
finite system. Our very lowest frequency modes show "quasi-localized"
resonances away from the jamming point; the spatial extent of these regions
increases as the jamming point is approached, as expected theoretically.
Throughout the remaining frequency range, our data show no signature of the
nearness of the jamming point and collapse well when properly rescaled with the
system size. Using Random Matrix Theory we derive the scaling relation ~
for the regime >> in dimensions.Comment: 6 pages, 7 figure
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